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This study not only elucidates the mechanisms of PARP1-mediated PXR E194 ribosylation in AILI but also identifies Sch B as the first specific inhibitor of this pathway, providing a theoretical basis for precision detoxification strategies targeting posttranslational modifications

In agerelated muscle decline research, sarcopenia is a common disorder in the elderly, characterized by reduced muscle mass, decreased muscle strength, and impaired muscle function, which severely affects quality of life.Animal experiments have confirmed that 5amino1mq tablets effectively improve muscle function and delay muscle decline in aged mice

Am J Physiology-Gastrointestinal Liver Physiol

10.1172/JCI59755 69 MengX.AnX.ZhouL.FuB.JiaL

W., Chung, J